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Under an Elsevier user license. We described changes in gut microbiota using a culture-independent approach based on pyrosequencing of the V3—V4 region of the bacterial 16S rRNA gene. Published by Elsevier Ltd.

Nitrofurantoin treatment correlated with a reduced relative proportion of the genus Clostridium and an increased proportion of the genus Faecalibacterium. Malhotra-Kumar 6 7 C. Published by Elsevier Ltd.

Nitrofurantoin treatment correlated with a reduced relative proportion of the genus Clostridium and an increased proportion of the genus Faecalibacterium. Published by Elsevier Ltd. Recommended articles Citing articles 0.

Malhotra-Kumar 6 7 C. We described changes in gut microbiota using a culture-independent approach based on pyrosequencing of the V3—V4 region of the bacterial 16S rRNA gene. Author links open overlay panel A.

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Ciprofloxacin had a significant global impact on the gut microbiota whereas nitrofurantoin did not. Abstract Recent treatment guidelines for uncomplicated urinary tract infections UTIs discourage fluoroquinolone prescription because of collateral damage to commensal microbiota, but the ecologic impact of alternative agents has not been evaluated by culture-free techniques.

The end of ciprofloxacin treatment correlated with a reduced proportion of Bifidobacterium Actinobacteria , Alistipes Bacteroidetes and four genera from the phylum Firmicutes Faecalibacterium, Oscillospira, Ruminococcus and Dialister and an increased relative abundance of Bacteroides Bacteroidetes and the Firmicutes genera Blautia, Eubacterium and Roseburia.

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Substantial recovery had occurred 4 weeks later. All groups were similar at baseline. Malhotra-Kumar 6 7 C.

Published by Elsevier Ltd. The end of ciprofloxacin treatment correlated with a reduced proportion of Bifidobacterium Actinobacteria , Alistipes Bacteroidetes and four genera from the phylum Firmicutes Faecalibacterium, Oscillospira, Ruminococcus and Dialister and an increased relative abundance of Bacteroides Bacteroidetes and the Firmicutes genera Blautia, Eubacterium and Roseburia.

Malhotra-Kumar 6 7 C.

Martinez de Tejada 4 J. Ciprofloxacin had a significant global impact on the gut microbiota whereas nitrofurantoin did not. We prospectively collected faecal samples at three time points from ambulatory patients with UTIs treated with ciprofloxacin or nitrofurantoin, patients not requiring antibiotics and household contacts of ciprofloxacin-treated patients.

All groups were similar at baseline. Recent treatment guidelines for uncomplicated urinary tract infections UTIs discourage fluoroquinolone prescription because of collateral damage to commensal microbiota, but the ecologic impact of alternative agents has not been evaluated by culture-free techniques.

Malhotra-Kumar 6 7 C.

Martinez de Tejada 4 J. Substantial recovery had occurred 4 weeks later. Published by Elsevier Ltd. Ciprofloxacin had a significant global impact on the gut microbiota whereas nitrofurantoin did not. We prospectively collected faecal samples at three time points from ambulatory patients with UTIs treated with ciprofloxacin or nitrofurantoin, patients not requiring antibiotics and household contacts of ciprofloxacin-treated patients.

Published by Elsevier Ltd. Author links open overlay panel A.

This study supports use of nitrofurantoin over fluoroquinolones for treatment of uncomplicated UTIs to minimize perturbation of intestinal microbiota. The end of ciprofloxacin treatment correlated with a reduced proportion of Bifidobacterium Actinobacteria , Alistipes Bacteroidetes and four genera from the phylum Firmicutes Faecalibacterium, Oscillospira, Ruminococcus and Dialister and an increased relative abundance of Bacteroides Bacteroidetes and the Firmicutes genera Blautia, Eubacterium and Roseburia.

Recommended articles Citing articles 0.

Substantial recovery had occurred 4 weeks later. Ciprofloxacin had a significant global impact on the gut microbiota whereas nitrofurantoin did not.

This study supports use of nitrofurantoin over fluoroquinolones for treatment of uncomplicated UTIs to minimize perturbation of intestinal microbiota. All groups were similar at baseline. Malhotra-Kumar 6 7 C. Nitrofurantoin treatment correlated with a reduced relative proportion of the genus Clostridium and an increased proportion of the genus Faecalibacterium.

Author links open overlay panel A. Stewardson 1 5 N. Malhotra-Kumar 6 7 C. We described changes in gut microbiota using a culture-independent approach based on pyrosequencing of the V3—V4 region of the bacterial 16S rRNA gene. Published by Elsevier Ltd.

Recent treatment guidelines for uncomplicated urinary tract infections UTIs discourage fluoroquinolone prescription because of collateral damage to commensal microbiota, but the ecologic impact of alternative agents has not been evaluated by culture-free techniques.

Martinez de Tejada 4 J.

This study supports use of nitrofurantoin over fluoroquinolones for treatment of uncomplicated UTIs to minimize perturbation of intestinal microbiota. Recommended articles Citing articles 0. Stewardson 1 5 N. Nitrofurantoin treatment correlated with a reduced relative proportion of the genus Clostridium and an increased proportion of the genus Faecalibacterium.

Recent treatment guidelines for uncomplicated urinary tract infections UTIs discourage fluoroquinolone prescription because of collateral damage to commensal microbiota, but the ecologic impact of alternative agents has not been evaluated by culture-free techniques. Ciprofloxacin had a significant global impact on the gut microbiota whereas nitrofurantoin did not.

Published by Elsevier Ltd. All groups were similar at baseline. Abstract Recent treatment guidelines for uncomplicated urinary tract infections UTIs discourage fluoroquinolone prescription because of collateral damage to commensal microbiota, but the ecologic impact of alternative agents has not been evaluated by culture-free techniques.

Recommended articles Citing articles 0. Substantial recovery had occurred 4 weeks later. Martinez de Tejada 4 J.



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